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Annals of Oncology Advance Access originally published online on September 9, 2007
Annals of Oncology 2007 18(10):1591-1593; doi:10.1093/annonc/mdm342
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© 2007 European Society for Medical Oncology

editorial

Current role of allogeneic stem cell transplantation in breast cancer

A. M. Carella1,* and M. Bregni2

1 Division of Hematology I, Azienda Ospedaliera Universitaria San Martino, Genova
2 Strategic Program in Oncology, Istituto San Raffaele, Milano, Italy

* (E-mail: angelomichele.carella@hsanmartino.it)

The first 150 words of the full text of this article appear below.

The majority of patients with metastatic breast cancer will relapse and will die of their disease. Allogeneic stem cell transplantation (AlloSCT) with myeloablative conditioning regimens may provide cytoreduction and eradication of disease with two advantages: a cancer free-graft and an immune-mediated graft-versus-tumor (GVT) effect mediated by the donor's immune cells. The first report of an AlloSCT in solid tumors has been published in 1996 [1]. Since then, several small series have been published, especially in renal cell and breast cancer [2, 3–11]. With reduced-intensity conditioning regimens (RICT), the goal of transplantation is the achievement of a full donor engraftment and the induction of a GVT effect, rather than chemotherapy-related cytoreduction. Clinical responses suggestive of a GVT effects have been reported, and more than 1000 patients with refractory and advanced solid tumors, to date, have undergone RICT in EBMT centers.

graft-versus-breast cancer effect
In 1996, Eibl et . . . [Full Text of this Article]

reduced-intensity conditioning regimens for AlloSCT
will allografting have a place in the busy therapeutic armamentarium of breast cancer?

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