Skip Navigation


Annals of Oncology Advance Access originally published online on October 23, 2006
Annals of Oncology 2007 18(1):29-35; doi:10.1093/annonc/mdl320
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
18/1/29    most recent
mdl320v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ou, S-H.
Right arrow Articles by Anton-Culver, H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ou, S-H.
Right arrow Articles by Anton-Culver, H
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 European Society for Medical Oncology

epidemiology

Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology

S-HI Ou1,3,*, JA Zell1,3, A Ziogas2,3 and H Anton-Culver2,3

1 Chao Family Comprehensive Cancer Center, Division of Hematology/Oncology
2 Genetic Epidemiology Research Institute
3 Division of Epidemiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, USA

* Correspondence to: Dr S.-H. I. Ou, Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, 101 The City Drive South, Building 56, Room 241, RT 81, Orange, CA 92868-3298, USA. Tel: +1-714-456-8104; Fax: +1-714-456-2242; E-mail: ignatius.ou{at}uci.edu

Background: This study examined potential survival differences among nasopharyngeal carcinoma (NPC) patients from various ethnicities in the United States.

Patients and methods: A total of 2436 newly diagnosed NPC patients from 1992 to 2002 were analyzed from the population-based Surveillance, Epidemiology, and End Results (SEER) program. Five-year survival rate estimates and Kaplan–Meier survival curves were calculated. Cox proportional hazard ratios (HRs) were used to identify independent prognostic factors for survival.

Results: By multivariate analyses, early age of diagnosis, localized stage at presentation (versus distant, HR = 0.35; P < 0.0001), radiation therapy (versus none; HR = 0.48; P < 0.0001), undifferentiated non-keratinizing carcinoma (versus keratinizing squamous cell carcinoma; HR = 0.67; P < 0.0001), and Chinese ethnicity (versus Caucasian; HR = 0.78; P = 0.0010) were associated with improved survival. Within keratinizing squamous cell carcinoma histology, the survival advantage of Chinese patients remained even after adjustment for other prognostic factors.

Conclusions: The significant survival advantage of Chinese NPC patients within the keratinizing squamous cell carcinoma histology contributed largely to Chinese ethnicity being an independent and favorable prognostic factor for survival in NPC.

Key words: epidemiology, ethnicity, nasopharyngeal carcinoma, prognosis, SEER


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ChestHome page
D. J. Raz, J. A. Zell, S-H. I. Ou, D. R. Gandara, H. Anton-Culver, and D. M. Jablons
Natural History of Stage I Non-Small Cell Lung Cancer: Implications for Early Detection
Chest, July 1, 2007; 132(1): 193 - 199.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.