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Annals of Oncology Advance Access originally published online on October 23, 2006
Annals of Oncology 2007 18(1):29-35; doi:10.1093/annonc/mdl320
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© 2006 European Society for Medical Oncology

epidemiology

Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology

S-HI Ou1,3,*, JA Zell1,3, A Ziogas2,3 and H Anton-Culver2,3

1 Chao Family Comprehensive Cancer Center, Division of Hematology/Oncology
2 Genetic Epidemiology Research Institute
3 Division of Epidemiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, USA

* Correspondence to: Dr S.-H. I. Ou, Chao Family Comprehensive Cancer Center, University of California Irvine Medical Center, 101 The City Drive South, Building 56, Room 241, RT 81, Orange, CA 92868-3298, USA. Tel: +1-714-456-8104; Fax: +1-714-456-2242; E-mail: ignatius.ou{at}uci.edu

Background: This study examined potential survival differences among nasopharyngeal carcinoma (NPC) patients from various ethnicities in the United States.

Patients and methods: A total of 2436 newly diagnosed NPC patients from 1992 to 2002 were analyzed from the population-based Surveillance, Epidemiology, and End Results (SEER) program. Five-year survival rate estimates and Kaplan–Meier survival curves were calculated. Cox proportional hazard ratios (HRs) were used to identify independent prognostic factors for survival.

Results: By multivariate analyses, early age of diagnosis, localized stage at presentation (versus distant, HR = 0.35; P < 0.0001), radiation therapy (versus none; HR = 0.48; P < 0.0001), undifferentiated non-keratinizing carcinoma (versus keratinizing squamous cell carcinoma; HR = 0.67; P < 0.0001), and Chinese ethnicity (versus Caucasian; HR = 0.78; P = 0.0010) were associated with improved survival. Within keratinizing squamous cell carcinoma histology, the survival advantage of Chinese patients remained even after adjustment for other prognostic factors.

Conclusions: The significant survival advantage of Chinese NPC patients within the keratinizing squamous cell carcinoma histology contributed largely to Chinese ethnicity being an independent and favorable prognostic factor for survival in NPC.

Key words: epidemiology, ethnicity, nasopharyngeal carcinoma, prognosis, SEER


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