Skip Navigation

Annals of Oncology 2006 17(Supplement 7):vii27-vii29; doi:10.1093/annonc/mdl945
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Macaluso, M.
Right arrow Articles by Giordano, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Macaluso, M.
Right arrow Articles by Giordano, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2006 European Society for Medical Oncology

symposium article

Nuclear and cytoplasmic interaction of pRb2/p130 and ER-ß in MCF-7 breast cancer cells

M. Macaluso1,2,3, M. Montanari1,2, P. B. Noto1, V. Gregorio1,3, E. Surmacz1 and A. Giordano1,2,*

1 Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA; 2 Department of Human Pathology and Oncology University of Siena, Siena, Italy; 3 Section of Oncology, Department of Oncology; University of Palermo, Palermo, Italy

* Correspondence to: A. Giordano, Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, 19122-Philadelphia, PA, USA. Tel: 215-204-9520; Fax: 215-204-9519; E-mail: giordano{at}temple.edu

Estrogens exhibit important biological functions and influence several pathological processes of hormone-dependent diseases. The biological actions of estrogens require their interaction with two estrogen receptors (ER-{alpha} and ER-ß), which are ligand-dependent transcription factors. ER-{alpha} and ER-ß exhibit distinct tissue expression patterns as well as show different patterns of gene regulation. In addition, it has been suggested that ER-ß works as a counter partner of ER-{alpha} through inhibition of the transactivating functions of ER-{alpha}. For instance, ER-ß seems to play a different role in breast tumorigenesis than ER-{alpha}, as ER-ß decreased expression in breast cancer has been correlated with bad prognosis. Biological activities of ER-{alpha} and ER-ß could be controlled by a number of interacting proteins such as activators/inhibitors, ligand binding and kinases. We have previously reported that pRb2/p130, retinoblastoma related protein, could be involved in the silencing of ER-{alpha} gene during breast tumorigenesis. Here, we report that ER-ß and pRb2/p130 proteins co-immunoprecipitate in both nucleus and cytoplasm of MCF-7 breast cancer cells. Our hypothesis is that the interaction of pRb2/130 with ER-ß may have a functional significance in regulating ER-ß activity.

Key words: estrogens, estrogen receptors, pRb2/130, breast cancer


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.