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Annals of Oncology 2006 17(Supplement 5):v52-v54; doi:10.1093/annonc/mdj950
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© 2006 European Society for Medical Oncology

symposium article

Chemo-radiotherapy in non-small cell lung cancer: the role of gemcitabine

L. Trodella1,*, R. M. D'Angelillo1, S. Ramella1, F. Cellini1, M. Ciresa1, A. Cesario2,3 and P. Granone2

1 Radiotherapy Unit, University Campus Bio-Medico, Rome; 2 Division of General Thoracic Surgery, Catholic University, Rome; 3 Clinical Respiratory Pathology Translational Lab, IRCCS San Raffaele, Rome, Italy

* Correspondence to: Dr L. Trodella, Radiotherapy Unit, University Campus Bio-Medico, Via E. Longoni 47 – 00155 Rome, Italy. Tel +39-622541420; Fax +39-62254143; E-mail l.trodella{at}unicampus.it

Gemcitabine (2'-2'-difluorodeoxycytidine) is a well-known cytotoxic drug and a potent radio-enhancer. We herein report the in vitro evidence of its activity, and the clinical experiences when this drug is administered concurrently with radiation. The phase I–II trials are analyzed, focusing on the recent ability to deliver irradiation with low incidence of side effects.


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