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Annals of Oncology 2006 17(Supplement 4):iv8-iv11; doi:10.1093/annonc/mdj991
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© 2006 European Society for Medical Oncology

symposium article

Managing large cell lymphoma

C. Gisselbrecht* and N. Mounier

Institute for Hematology, Hôpital Saint Louis, Paris, France

* Correspondence to: C. Gisselbrecht, Institut d'Hématologie, INSERM U728, Hôpital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris. France. Tel: +33-1-42-49-92-96; Fax: +33-1 42-49-96-41; E-mail: christian.gisselbrecht{at}sls.ap-hop-paris.fr

Rituximab has greatly improved standard cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, but prospects remain poor in patients with adverse risk factors. We need to know whether the addition of rituximab also improves the efficacy of more intensive treatments and how to use molecular profiling to guide us in introducing other novel agents.

Key words: large cell lymphoma, risk factors, rituximab, chemotherapy, autologous stem cell transplantation


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