Annals of Oncology Advance Access originally published online on June 20, 2006
Annals of Oncology 2006 17(9):1393-1398; doi:10.1093/annonc/mdl136
© 2006 European Society for Medical Oncology
breast cancer |
Baseline MRI delivery characteristics predict change in invasive ductal breast carcinoma PET metabolism as a result of primary chemotherapy administration
1 Department of Radiology, University of Aberdeen, Scotland, UK
3 Department of Surgery, University of Aberdeen, Scotland, UK
4 Department of School of Medical Sciences, University of Aberdeen, Scotland, UK
2 Department of Nuclear Medicine, Grampian University Hospitals NHS Trust, Foresterhill, Aberdeen, Scotland, UK
5 Department of Clinical Oncology, Aberdeen Royal Infirmary, Grampian University Hospitals NHS Trust, Foresterhill, Aberdeen, Scotland, UK
*Correspondence to: Dr S. I. K. Semple, Lilian Sutton Building, Department of Radiology, University of Aberdeen AB25 2ZD, Scotland, UK. Tel: +44-1224559725; Fax: +44-1224559718; E-mail: s.semple{at}abdn.ac.uk
Background: The aim of the study was to investigate whether pre-therapy vascular delivery assessment [using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)] can predict reduction in breast cancer metabolism [detected using 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (18F–FDG-PET)] after a single cycle of chemotherapy. Reduction in 18F-FDG PET metabolism has previously been shown to correlate with histological response to primary chemotherapy.
Patients and methods: Seventeen patients with large or locally advanced invasive ductal carcinomas of the breast were imaged using DCE-MRI and 18F-FDG-PET prior to therapy and 20 days after the first cycle of chemotherapy. MRI data were analysed using a multi-compartment model. PET data were analysed using standardised uptake value (SUV) analysis.
Results: A significant association (P <0.05) was observed between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism resulting from administration of one cycle of chemotherapy.
Conclusions: A relationship was demonstrated between pre-therapy DCE-MRI vascular parameters and the reduction in PET metabolism after a single cycle of chemotherapy. This suggests that reduction in PET metabolism as a result of chemotherapy may be dependent, at least in part, on pre-therapy vascular delivery. These pre-therapy vascular characteristics may be suitable for use as a surrogate measure for initial chemotherapy delivery, a key factor in chemotherapeutic efficacy.
Key words: breast cancer, dynamic MRI, 18F-FDG PET, chemotherapy, efficacy, delivery
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Vriens, H. W.M. van Laarhoven, J. J.A. van Asten, P. F.M. Krabbe, E. P. Visser, A. Heerschap, C. J.A. Punt, L.-F. de Geus-Oei, and W. J.G. Oyen Chemotherapy Response Monitoring of Colorectal Liver Metastases by Dynamic Gd-DTPA-Enhanced MRI Perfusion Parameters and 18F-FDG PET Metabolic Rate J. Nucl. Med., November 1, 2009; 50(11): 1777 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. K. Dunnwald, J. R. Gralow, G. K. Ellis, R. B. Livingston, H. M. Linden, J. M. Specht, R. K. Doot, T. J. Lawton, W. E. Barlow, B. F. Kurland, et al. Tumor Metabolism and Blood Flow Changes by Positron Emission Tomography: Relation to Survival in Patients Treated With Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer J. Clin. Oncol., September 20, 2008; 26(27): 4449 - 4457. [Abstract] [Full Text] [PDF]
|
|