Annals of Oncology Advance Access originally published online on February 23, 2006
Annals of Oncology 2006 17(5):780-784; doi:10.1093/annonc/mdl014
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© 2006 European Society for Medical Oncology
18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) visualizes follicular lymphoma irrespective of grading
Departments of 1 Internal Medicine I, 2 Nuclear Medicine and 3 Radiology, Medical University Vienna, Austria
* Correspondence to: Dr M. Hoffmann, Department of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18–20, A-1090 Vienna. Tel: +43 (0)1 40400 5274; Fax: +43 (0)1 40400 5552; E-mail: martha.hoffmann{at}meduniwien.ac.at
Background: 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) has become a routine measure for staging and follow-up of patients with aggressive lymphoma. By contrast, its usefulness to visualize indolent lymphomas characterized by a lower cellular turnover has not clearly been defined. We have investigated accuracy and clinical usefulness of 18F-FDG-PET in patients with follicular lymphoma (FL).
Patients and methods: A total of 64 patients with FL WHO grade I – III (48, 5, and 11 patients) were imaged at our institution to assess the value of 18F-FDG-PET for imaging of FL of different gradings. A total of 115 scans (48 before therapy and 67 for response assessment after treatment) were performed, and findings were compared to conventional staging including CT-scan of thorax and abdomen, sonography of lymph nodes and bone marrow biopsy.
Results: Overall, 18F-FDG-PET had a sensitivity of 98%, a specificity of 94%, a positive predictive value of 95% and a negative predictive value of 98%. These results were significantly more accurate (P = 0.023) than the conventional radiology studies. There was no significant difference (P = 0.093) in the accuracy between patients with indolent (WHO grade I and II) versus aggressive FL (WHO grade III).
Conclusion: 18F-FDG-PET scan is a reliable method for staging and follow up of patients with nodal FL irrespective of tumor grading.
Key words: 18F-FDG-PET, follicular lymphoma, grading, staging
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