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Annals of Oncology Advance Access originally published online on May 26, 2006
Annals of Oncology 2006 17(11):1719-1720; doi:10.1093/annonc/mdl112
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© 2006 European Society for Medical Oncology

letters to the editor

Tyrosine kinase inhibitors causing hypothyroidism in a patient on levothyroxine

JWB de Groot1, TP Links1 and WTA van der Graaf2,*

1 Department of Endocrinology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands
2 Department of Medical Oncology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands

*(E-mail: w.t.a.van.der.graaf@int.umcg.nl)

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A 73-year-old woman was admitted with fatigue, nausea, cold-intolerance, hair-loss, brittle nails, progressive weakness and impressive facial oedema 6 months after starting imatinib (600 mg daily) for metastatic gastrointestinal stromal tumour (GIST, Figure 1) elsewhere. Previously, she had thyroidectomy and 131I-ablation for follicular thyroid carcinoma. She always had normal thyroid function using 200 µg levothyroxine daily. She also used alendronic acid, hydrochlorothiazide and quinapril. We attributed her complaints to . . . [Full Text of this Article]


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