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Annals of Oncology Advance Access originally published online on April 22, 2005
Annals of Oncology 2005 16(7):1207-1208; doi:10.1093/annonc/mdi206
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© 2005 European Society for Medical Oncology

Letter to the Editor

Jaw avascular bone necrosis associated with long-term use of biphosphonates

The first 10% of the full text of this article appears below.

Bisphosphonates are currently used to prevent bone complications and to treat malignant hypercalcemia in patients with multiple myeloma, or bone metastases from breast and prostate cancers [1Go].

Within the last year we observed 10 patients who developed jaw bone necrosis while on treatment with zoledronic acid (Zometa®; Novartis) or pamidronate. All the patients . . . [Full Text of this Article]

G. Sanna*, M. G. Zampino, G. Pelosi, F. Nolè and A. Goldhirsch

Istituto Europeo di Oncologia, Via Ripamonti 435, 20141 Milano, Italy

(*Email: giuseppina.sanna@ieo.it)


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