Annals of Oncology Advance Access originally published online on April 22, 2005
Annals of Oncology 2005 16(7):1207-1208; doi:10.1093/annonc/mdi206
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© 2005 European Society for Medical Oncology
Letter to the Editor |
Jaw avascular bone necrosis associated with long-term use of biphosphonates
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Bisphosphonates are currently used to prevent bone complications and to treat malignant hypercalcemia in patients with multiple myeloma, or bone metastases from breast and prostate cancers [1
].
Within the last year we observed 10 patients who developed jaw bone necrosis while on treatment with zoledronic acid (Zometa®; Novartis) or pamidronate. All the patients
Istituto Europeo di Oncologia, Via Ripamonti 435, 20141 Milano, Italy
(*Email: giuseppina.sanna@ieo.it)
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