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Annals of Oncology Advance Access originally published online on March 23, 2005
Annals of Oncology 2005 16(5):835-836; doi:10.1093/annonc/mdi144
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© 2005 European Society for Medical Oncology

Letters

The effects of capecitabine in Raynaud's disease: a case report

J. Coward, N. Maisey and D. Cunningham*

Royal Marsden Hospital, Sutton, UK

* Email: david.cunningham@icr.ac.uk

The first 10% of the full text of this article appears below.

5-Fluorouracil (5-FU) is one of a number of chemotherapeutic agents associated with cardiovascular toxicities, with an incidence ranging from 2% to 10% [1Go–3Go]. Side-effects including angina, arrhythmias, ventricular dysfunction and myocardial infarction, along with the induction and exacerbation of Raynaud's disease, are well documented. With the increasing use of the oral 5-FU prodrug capecitabine, recent reports suggest that its cardiotoxic incidence is similar to that of 5-FU . . . [Full Text of this Article]


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