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Annals of Oncology Advance Access originally published online on February 16, 2005
Annals of Oncology 2005 16(4):673; doi:10.1093/annonc/mdi101
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© 2005 European Society for Medical Oncology

Letters

Reply to the article "Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity" by V. R. Rozados et al. (Ann Oncol 2004; 15: 1543–1550): ... and in humans?

T. De Pas*, M. Colleoni, L. Orlando, G. Masci, A. Rocca, C. Catania, G. Curigliano, S. Manzoni, A. Goldhirsch and F. de Braud

Department of Medical Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy

* Email: tommaso.de-pas@ieo.it

The first 10% of the full text of this article appears below.

We congratulate Rozados et al. [1Go] on conducting this important clinical trial, which investigates the antitumour effect of a metronomic administration of low-dose cyclophosphamide (CTX) in sarcoma rat tumour models.

The use of ‘metronomic’ drug delivery is increasing in solid . . . [Full Text of this Article]


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