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Annals of Oncology 15:850-851, 2004
© 2004 European Society for Medical Oncology

Obesity and breast cancer prognosis: an expanding body of evidence

J. J. Dignam*,1,2 and E. P. Mamounas3,4

1 Department of Health Studies, University of Chicago, Chicago, IL; 2 University of Chicago Cancer Research Center, Chicago, IL; 3 Aultman Cancer Center, Canton, OH; 4 Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA

*E-mail: jdignam@health.bsd.uchicago.edu

The first 10% of the full text of this article appears below.

In recent years, interest has grown in the relationship between obesity and cancer. Increasingly, obesity has been identified as a significant risk factor for many cancers and, after tobacco use, may be the single greatest modifiable cancer risk factor [1–3]. Obesity also may affect prognosis after cancer through numerous pathways, including associated adverse disease features, hormonal influences, comorbidities that can interfere with treatment and other as yet unknown mechanisms. As earlier detection and more successful treatments continue to improve the long-term survival of cancer patients, obesity may become an even more important facet of cancer management.

For breast cancer, a clear association between obesity and disease risk seems to have been established (particularly in post-menopausal women [4]), and new studies confirming this observation and investigating explanatory hypotheses for the relationship continue to appear . . . [Full Text of this Article]

Acknowledgements


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