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Annals of Oncology 15:550-558, 2004
© 2004 European Society for Medical Oncology

Review Article

Treatment for Waldenstrom’s macroglobulinemia

Received 16 September 2003; accepted 30 September 2003

ABSTRACT

Waldenstrom’s macroglobulinemia is a rare form of indolent lymphoma characterized by the production of a monoclonal immunoglobulin M protein, and complications such as hyperviscosity, cytopenias and peripheral neuropathy. Conventional treatment approaches are based on alkylators or nucleoside analogs, but in the absence of a clearly superior regimen, a broad array of alternative therapies exists. Choices range from biological agents to combination chemotherapy to stem-cell transplantation. A rational approach therefore must be based on careful patient assessment and individualization of therapy.

C. I. Chen*

Princess Margaret Hospital/Ontario Cancer Institute, Toronto, Ontario, Canada

Key words: Waldenstrom’s macroglobulinemia, lymphoplasmacytic lymphoma, therapy, alkylating agents, nucleoside analogs, IgM monoclonal protein


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