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Annals of Oncology 14:969-970, 2003
© 2003 European Society for Medical Oncology

Editorial

Targeting antihormone resistance in breast cancer: a simple solution

V. C. Jordan

The first 10% of the full text of this article appears below.

During the past 30 years a dramatic change has occurred in the approach to the treatment of breast cancer. Thirty years ago, non-specific combination cytotoxic chemotherapy was going to cure breast cancer, advanced breast cancer was the only stage being treated with drugs and the estrogen receptor (ER) was considered a potential predictive test for identifying the one in three women who would respond to endocrine ablative surgery.

These changes occurred as a result of two principal factors: ER evolved from being viewed as a predictive marker of endocrine responsiveness to becoming a molecular target for tumor . . . [Full Text of this Article]


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