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Annals of Oncology 14:497-498, 2003
© 2003 European Society for Medical Oncology

Letters to the Editor

Skin testing and hypersensitivity reactions to oxaliplatin

C. Garufi*,1, A. Cristaudo2, B. Vanni1, E. Bria1, A. M. Aschelter1, B. Santucci2 and E. Terzoli1

1 Oncologia Medica C, Istituto Regina Elena, Roma; 2 Istituto San Gallicano, Roma, Italy

*E-mail: garufi@sirio-oncology.it

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Oxaliplatin (L-OHP) is a third-generation platinum (Pt) analogue where the Pt atom is linked to a diaminocyclohexane structure joined to oxalic acid. It has been found to be active as a single agent in advanced colorectal cancer [1], to synergise with 5-fluorouracil (5-FU) and folinic acid (FA) [2], and to have a cumulative sensitive neuropathy as the dose-limiting toxicity. Allergic reactions to L-OHP have been described in the literature, including skin rashes and itching, redness of the face, dizziness, shortness of breath and anxiety [3, . . . [Full Text of this Article]


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