Annals of Oncology 14:461-466, 2003
© 2003 European Society for Medical Oncology
Original Paper |
Epidermal growth factor-based cancer vaccine for non-small-cell lung cancer therapy
1 Center of Molecular Immunology; 2 Center of Medical Surgical Research; 3 National Institute of Oncology; 4 Hermanos Ameijeiras Hospital, Havana, Cuba
Received 26 April 2002; revised 16 September 2002; accepted 14 October 2002
Background:
The role that growth factors and their receptors play in human cancer growth and progression makes them interesting targets for novel treatment modalities. Our approach consisted of active immunotherapy with the epidermal growth factor (EGF). Two pilot clinical trials were conducted to examine the safety and immunogenicity of a five-dose immunization protocol and to compare different adjuvants and treatment designs.
Patients and methods:
Forty patients with advanced non-small-cell lung cancer were enrolled in both trials. They were randomized to be treated with aluminum hydroxide or montanide ISA 51 as adjuvants in the EGF vaccine preparation. The use of cyclophosphamide prevaccination treatment was evaluated in the second trial.
Results:
Pooled data from both trials showed that the use of montanide as adjuvant increased the percentage of good antibody responders (GAR). Cyclophosphamide prevaccination treatment did not provoke improvements in antibody response. GAR had a significant increase in survival as compared with poor antibody responders. Response duration was also related to a significant improvement in survival rates.
Conclusions:
Vaccination with five doses of EGF vaccine is safe and immunogenic. Montanide ISA 51 increased the percentage of GAR. There is a direct relationship between anti-EGF antibody titers and immune response duration with survival time.
Key words: cancer vaccine, epidermal growth factor, non-small-cell lung cancer
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Gridelli, A. Rossi, P. Maione, M. L. Ferrara, V. Castaldo, and P. C. Sacco Vaccines for the Treatment of Non-Small Cell Lung Cancer: A Renewed Anticancer Strategy Oncologist, September 1, 2009; 14(9): 909 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. N. Vinageras, A. de la Torre, M. O. Rodriguez, M. C. Ferrer, I. Bravo, M. M. del Pino, D. A. Abreu, S. A. Brooks, R. Rives, C. del Castillo Carrillo, et al. Phase II Randomized Controlled Trial of an Epidermal Growth Factor Vaccine in Advanced Non-Small-Cell Lung Cancer J. Clin. Oncol., March 20, 2008; 26(9): 1452 - 1458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Garcia, E. Neninger, A. de la Torre, I. Leonard, R. Martinez, C. Viada, G. Gonzalez, Z. Mazorra, A. Lage, and T. Crombet Effective Inhibition of the Epidermal Growth Factor/Epidermal Growth Factor Receptor Binding by Anti-Epidermal Growth Factor Antibodies Is Related to Better Survival in Advanced Non-Small-Cell Lung Cancer Patients Treated with the Epidermal Growth Factor Cancer Vaccine Clin. Cancer Res., February 1, 2008; 14(3): 840 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Bolonaki, A. Kotsakis, E. Papadimitraki, D. Aggouraki, G. Konsolakis, A. Vagia, C. Christophylakis, I. Nikoloudi, E. Magganas, A. Galanis, et al. Vaccination of Patients With Advanced Non-Small-Cell Lung Cancer With an Optimized Cryptic Human Telomerase Reverse Transcriptase Peptide J. Clin. Oncol., July 1, 2007; 25(19): 2727 - 2734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O'Mahony, S. Kummar, and M. E. Gutierrez Non-Small-Cell Lung Cancer Vaccine Therapy: A Concise Review J. Clin. Oncol., December 10, 2005; 23(35): 9022 - 9028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Raez, S. Fein, and E. R. Podack Lung Cancer Immunotherapy Clin. Med. Res., November 1, 2005; 3(4): 221 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Giaccone Epidermal Growth Factor Receptor Inhibitors in the Treatment of Non-Small-Cell Lung Cancer J. Clin. Oncol., May 10, 2005; 23(14): 3235 - 3242. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Friedman, C. S. Bangur, E. J. Zasloff, L. Fan, T. Wang, Y. Watanabe, and M. Kalos Molecular and Immunological Evaluation of the Transcription Factor SOX-4 as a Lung Tumor Vaccine Antigen J. Immunol., March 1, 2004; 172(5): 3319 - 3327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mine, Y. Sato, M. Noguchi, T. Sasatomi, R. Gouhara, N. Tsuda, S. Tanaka, H. Shomura, K. Katagiri, T. Rikimaru, et al. Humoral Responses to Peptides Correlate with Overall Survival in Advanced Cancer Patients Vaccinated with Peptides Based on Pre-existing, Peptide-Specific Cellular Responses Clin. Cancer Res., February 1, 2004; 10(3): 929 - 937. [Abstract] [Full Text] [PDF]
|
|