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Annals of Oncology 14:1607-1615, 2003
© 2003 European Society for Medical Oncology

Review Article

Progress in the development and acquisition of anticancer agents from marine sources

M. L. Amador1,+, J. Jimeno2, L. Paz-Ares3, H. Cortes-Funes3 and M. Hidalgo1

1 The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA; 2 Pharmamar, SA, Madrid; 3 Hospital Universitario Doce de Octubre, Medical Oncology Department, Madrid, Spain

Received 3 April 2003; revised 30 April 2003; accepted 3 June 2003

Key words: aplidine, bryostatin, cancer, dolastatin, ET-743, marine

The first 150 words of the full text of this article appear below.

Introduction

Since ancient times, nature has been an important source of medicines: a fact illustrated by the large number of natural products currently in use in medical practice. These products have been identified and developed through folklore knowledge of the medicinal properties of plants, animal extracts and minerals. Microorganisms are also a prolific source of novel agents. They have yielded some of the most important pharmaceutical products, such as the antibiotics, penicillin and aminoglycosides, which represent landmarks in the history of medicine.

Almost 60% of drugs approved for cancer treatment are of natural origin. Vincristine, irinotecan, etoposide, taxanes and camptothecines are all examples of plant-derived compounds. Dactinomicine, anthracyclines, mitomycin and bleomycin are anticancer agents derived from microbial sources [1].

Although marine compounds are under-represented in current pharmacopoeia, it is anticipated that the aquatic environment will become an invaluable source of novel compounds in the future. The marine ecosystem represents . . . [Full Text of this Article]

Sources, collection, screening and supply of marine anticancer agents

Marine-derived compounds in clinical development

Bryostatin-1
Didemnins
Dolastatins
Ectenaisdin 743 (ET-743)
Selected new natural marine products with promising applications in oncology

Conclusions


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