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Annals of Oncology 14:1588-1589, 2003
© 2003 European Society for Medical Oncology

Letters to the Editor

Onycholysis secondary to multiple paclitaxel 1-hour infusions: possible role for its vehicle (Cremophor EL)

U. De Giorgi*,1, G. Rosti1, M. Monti1, G. L. Frassineti2 and M. Marangolo1

1 Istituto Oncologico Romagnolo, Department of Oncology, Santa Maria delle Croci Hospital, Ravenna; 2 Istituto Oncologico Romagnolo, Department of Oncology, Pierantoni Hospital, Forli, Italy

*E-mail: ugo_degiorgi@yahoo.com

The first 10% of the full text of this article appears below.

We read with interest the clinical cases describe by Minisini et al. and their review of the literature related to nail toxicity associated with taxane therapy [1]. Nail changes are reported with docetaxel given as 3-weekly or weekly schedules, and with weekly paclitaxel. The authors suggested that nail changes were based on taxane-induce vascular abnormalities (hematoma, hemorrhagic lesions) and neurotoxic damage (onycholysis). Previous reports focusing on onycholysis . . . [Full Text of this Article]


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