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Annals of Oncology 14:162-167, 2003
© 2003 European Society for Medical Oncology

Original Paper

Fibre intake and laryngeal cancer risk

C. Pelucchi1,+, R. Talamini2, F. Levi3, C. Bosetti1, C. La Vecchia1,4, E. Negri1, M. Parpinel2 and S. Franceschi5

1 Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milan; 2 Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano, Italy; 3 Registre Vaudois des Tumeurs, Institut Universitaire de Médecine Sociale et Préventive, Lausanne, Switzerland; 4 Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy; 5 International Agency for Research on Cancer, Lyon, France

Received 6 May 2002; revised 7 August 2002; accepted 10 September 2002

Background:

Consumption of vegetables, fruit and whole grain cereals has been inversely related to laryngeal cancer risk. Among the potential protective agents found in these foods, information on dietary fibres and laryngeal cancer risk are scanty.

Patients and methods:

A multi-centric, hospital-based case–control study was conducted on 527 patients with squamous-cell carcinoma of the larynx and 1297 non-neoplastic controls. Cases and controls, frequency matched by age, sex and study centre, were interviewed using a validated food frequency questionnaire.

Results:

Compared with the lowest quintile of fibre intake, the odds ratios (ORs) for the highest quintile were 0.3 [95% confidence interval (CI) 0.2–0.4] for total fibre, 0.3 (95% CI 0.2–0.5) for soluble non-cellulose polysaccharides (NCP) and for total insoluble fibre, including cellulose (OR = 0.3, 95% CI 0.2–0.4) and insoluble NCP (OR = 0.4, 95% CI 0.3–0.7). The ORs were 0.2 (95% CI 0.1–0.4) for fibre from vegetables, 0.5 (95% CI 0.3–0.7) from fruit and 1.1 (95% CI 0.6–1.9) from grains. The inverse association observed was similar among different subsites of laryngeal cancer, and consistent across strata of various covariates.

Conclusions:

This study found a strong inverse association between fibre intake and laryngeal cancer risk, which points to fibre as one of the beneficial components of vegetables and fruit.

Key words: case–control study, diet, risk factors, fibre, laryngeal cancer, subsite


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