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Annals of Oncology 13:23-29, 2002
© 2002 European Society for Medical Oncology

Viruses and Hodgkin's lymphoma

R. F. Jarrett1

1 LRF Virus Centre, Institute of Comparative Medicine, University of Glasgow, Glasgow, UK

Abstract

Hodgkin's lymphoma (HL) is unusual among human malignancies in that the epidemiology suggests an infectious aetiology. The Epstein–Barr virus (EBV) is associated with a proportion of cases and this association is believed to be causal. In these cases the Hodgkin and Reed–Sternberg (HRS) cells express the EBV-encoded proteins LMP1 and LMP2, which can mimic CD40 and the B cell receptor, respectively, and therefore may play a critical role in facilitating the survival of HRS cells. EBV-associated and non-EBV-associated HL cases have different epidemiological features and recent data suggest that delayed exposure to EBV is a risk factor for the development of EBV-associated HL in young adults. We suggest that HL can be divided into four entities on the basis of EBV status and age at presentation, with three groups of EBV-associated cases and a single group of EBV-negative cases. The aetiology of the latter cases is obscure although involvement of an infectious agent(s) is suspected.

epidemiology; Epstein–Barr virus; herpesvirus; Hodgkin's lymphoma; infectious mononucleosis; latent membrane protein


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