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Annals of Oncology 13:1169-1171, 2002
© 2002 European Society for Medical Oncology

Editorial

Cyclooxygenase-2 (COX-2) a new prognostic and predictive factor for ovarian cancer? Are all the criteria fulfilled?

M. L. Nasi and M. Castiglione

International Breast Cancer Study Group, Bern, Switzerland (E-mail: mcastiglione@sakk.ch)

The first 150 words of the full text of this article appear below.

Ovarian cancer is the most common gynecological malignancy, as well as the leading cause of death from gynecological cancers in the western world. The survival of patients with advanced epithelial ovarian cancer has clearly improved with the advances in surgery and more effective chemotherapy. Because long-term survival and cure are possible in patients who present with advanced ovarian cancer, the therapeutic strategy generally consists of aggressive surgery combined with chemotherapy. The combination of carboplatin and paclitaxel has been accepted as the treatment of choice, based on the results of large prospective randomized trials. Most patients who present with advanced disease will achieve a clinical complete remission after initial therapy. Unfortunately, the majority of these patients will relapse, and most of the relapsed patients are incurable. Median time to progression (TTP) will vary between 18 and 24 months. Although not curative, treatment of patients with recurrent ovarian cancer can result in . . . [Full Text of this Article]

Based on these findings, should we consider COX-2 expression as a new predictive factor, and possibly also prognostic factor, for patients with ovarian cancer?


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