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Annals of Oncology 13:331-333, 2002
© 2002 European Society for Medical Oncology

Letters to the Editor

Second-line treatment with docetaxel after failure of a platinum-based chemotherapy in squamous-cell head and neck cancer

G. Numico and M. Merlano

Oncologia Medica, Azienda Ospedaliera S.Croce e Carle, Via Michele Coppino 26, 12100 Cuneo, Italy (E-mail:gnumico@libero.it)

Second-line chemotherapy does not have a proven impact on survival or on quality of life in head and neck cancer patients. Furthermore, responses are rare and usually of brief duration. Similar figures are also reported for second-line treatment of non-small-cell lung cancer; response rates rarely exceed 10% and median survival is ~4 months. However, two recent randomized trials suggested a survival benefit when docetaxel, administered as a single agent, was compared with best supportive care [1] or to another drug (ifosfamide or vinorelbine) [2], although the response rates obtained in the experimental arms were 5.8% and . . . [Full Text of this Article]

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