Annals of Oncology 13:1839-1840, 2002
© 2002 European Society for Medical Oncology
Editorial |
Radioguided occult lesion localization (ROLL) in breast cancer: maximizing efficacy, minimizing mutilation
Divisions of 1 Nuclear Medicine, 2 Senology, European Institute of Oncology, Milan, Italy (E-mail: direzione.mnu@ieo.it)
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We began investigating radioguided sentinel node biopsy for breast cancer in 1995, following pioneering publications by Giuliano et al. [1] with blue dye mapping, and Krag et al. [2] with radioguided excision. We adopted serial lymphoscintigraphy to follow the movement of radiotracer from the injection site through the lymphatic ducts to the sentinel node [3].
Early problems included which tracer compound to use, and where exactly should it be injected? Lacking data,
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