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Annals of Oncology 13:1697-1698, 2002
© 2002 European Society for Medical Oncology

Editorial

New paradigms in oncological therapeutics: redefining combination chemotherapy

D. E. Brenner

2150 Cancer Center and Geriatrics Center, University of Michigan Medical Center, Ann Arbor, MI; and VA Medical Center, Ann Arbor, MI, USA (E-mail: dbrenner@umich.edu)

The first 10% of the full text of this article appears below.

Definitions

As oncological therapeutics evolve from cytotoxic-focused treatment to more mechanism-based interventions, it is time to redefine the terminology to more precisely reflect the tools being employed. Nuance counts; the widely used term for systemic cancer treatment with drugs, ‘chemotherapy’, carries with it well deserved negative connotations to the lay public. Among professionals, ‘chemotherapy’ implies treatment with cytotoxic agents, but can lead to confusion and miscommunication among healthcare team members, and from professionals to patients and their families.

Systemic cancer treatments include hormonal, immunological stimulatory, cytotoxic and molecular-targeted approaches. The efficacy, toxicities and mechanisms of action of these various modalities differ substantially. Lumping all of these treatments under the term ‘chemotherapy’, or even ‘multi-agent . . . [Full Text of this Article]

Future role of combined cytotoxic therapeutics

Targeted therapeutics

New concepts in combination oncological therapeutics


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