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Annals of Oncology 10:351-354, 1999
© 1999 European Society for Medical Oncology

brief-report

Preliminary results on the activity of oxaliplatin (L-OHP) in refractory/recurrent non-Hodgkin's lymphoma patients

N. Germann1, S. Brienza1, M. Rotarski1, J. F. Emile2, M. Di Palma1, M. Musset1, M. Reynes2, P. Soulie1, E. Cvitkovic1 and J. L. Misset1,

1Fédération des Maladies Sanguines, Immunitaires el Tumorales Villejuif, France
2Départemenl d'Analomopalhologie, Höpital Paid Brousse Villejuif, France

Prof. J. L. Misset, Fédération des Services des Maladies Sanguines et Tumorales, Höpital Paul Brousse, 14 Avenue Paul Vaillant Couturier, 94804 Villejuif, France

Background: Many patients with advanced NHL ultimately relapse and require salvage treatment. Oxaliplatin, a diamino-cyclohexane (DACH) platinum, has shown a differential spectrum of cytotoxicity with cisplatin, with activity in primary or secondary cisplatin-resistant solid tumors (colon and ovarian cancer). We report the tolerance/activity of this platinum derivate in previously-treated NHL patients.

Patients and methods: From July 1988 to February 1994, 22 patients (11 men, 11 women) with recurrent NHL received single-agent oxaliplatin (100–130 mg/m2 i.v. over two hours with antiemetic premedication, q three weeks). All had been previously treated (median number of prior chemotherapy regimens 2, range 1–7) ≥ 1 alkylating agent: 22 patients, anthracy-clines: 18 patients, cisplatin: four patients, and radiation: 11 patients. Fourteen patients (63%) had progessive disease as best response to their last chemotherapy, and were considered treatment-refractory. All histologies were centrally reviewed in accord with the R.E.A.L. Classification; they were: eight follicular, five MCL, three diffuse large cell, two MALT, one lymphoplasmocytoid, and three other.

Results: A total of 144 cycles were administered for a median number of 6 (range 1–30) per patient. The objective response rate was 40% (95% CI: 21–64), including one CR (MCL) and eight PRs (four follicular, two MCL, two MALT). The median response duration was 27 months (range 5–44). Treatment-related toxicity was limited to grade 1–2 nausea/vomiting and reversible grade 1–2 peripheral neuropathy in most of the patients.

Conclusion: Oxaliplatin is an active agent in relapsed/refractory NHL, including the MCL type. Its safety profile makes this agent a good candidate for the development of combined salvage regimens. Further phase II studies are needed to confirm these preliminary results.

monotherapy, non-Hodgkin's lymphoma, oxaliplatin, salvage therapy


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