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Annals of Oncology 1:409-414, 1990
© 1990 European Society for Medical Oncology

review-article

Review: 5-Fluorouracil cardiotoxicity: A critical review

W. J. Gradishar and E. E. Vokes

Department of Medicine, Section of Hematology-Oncology, Pritzker School of Medicine, University of Chicago Chicago, USA

Correspondence to: William J. Gradishar, M.D. Department of Medicine, Section of Hematology-Oncology Northwestern University School of Medicine 233 E. Erie, Suite 700 Chicago, IL 60611, USA

5-Fluorouracil is a commonly administered chemotherapy agent that has infrequently been associated with cardiotoxicity. This review highlights the clinical features of this syndrome as described in reports from the medical literature. Clinical and laboratory evidence supporting proposed underlying mechanisms are reviewed.

5-Fluorouracil, toxicity, angina, thrombosis, myocardial infarction, coronary spasm


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