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Annals of Oncology 15:841, 2004
© 2004 European Society for Medical Oncology

Failure of the International Prognostic Index to prognosticate outcome in primary gastric DLBC lymphoma

E. Ibrahim*,1 and A. Ezzat2

1 Department of Oncology, King Faisal Specialist Hospital & Research Centre, Jeddah; 2 King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

*E-mail: ezzibrahim@kfshrc.edu.sa

We read with interest the original article published in the Annals of Oncology by Binn et al. [1], addressing the role of surgery plus chemotherapy in the management of diffuse large B-cell gastric lymphoma. We would like to make a correction in this regard. The authors stated that their results support the prognostic value of the International Prognostic Index (IPI) in predicting survival outcome in localized gastric lymphoma, and in the next sentence they indicate that these results are in agreement with ours, published in 1999, in one of the largest published series about this disease [2]. In fact, according to our paper, the IPI failed to classify patients into prognostically meaningful risk strata. A modified prognostic index was developed and proved to be of more prognostic significance. However, we recommended that prospective validation of the proposed model be attempted. It might be of interest if the authors can re-examine their data according to our proposed model.

REFERENCES

1. Binn M, Ruskone-Fourmestraux A, Lepage E et al. Surgical resection plus chemotherapy versus chemotherapy alone: comparison of two strategies to treat diffuse large B-cell gastric lymphoma. Ann Oncol 2003; 14: 1751–1757.[Abstract/Free Full Text]

2. Ibrahim EM, Ezzat AA, Raja MA et al. Primary gastric non-Hodgkin’s lymphoma: clinical features, management, and prognosis of 185 patients with diffuse large B-cell lymphoma. Ann Oncol 1999; 10: 1441–1449.[Abstract/Free Full Text]


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