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Annals of Oncology 2009 20(Supplement 4):iv51-iv53; doi:10.1093/annonc/mdp127
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

ESMO clinical recommendations

Familial colorectal cancer risk: ESMO Clinical Recommendations

H. F. A. Vasen1,2, A. E. van der Meulen–de Jong2, W. H. de Vos tot Nederveen Cappel2, J. Oliveira3 and On behalf of the ESMO Guidelines Working Group*

1 The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden
2 Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands
3 Service of Medical Oncology, Portuguese Institute of Oncology, Lisbon, Portugal

* Correspondence to: ESMO Guidelines Working Group, ESMO Head Office, Via L. Taddei 4, CH-6962 Viganello-Lugano, Switzerland; E-mail: clinicalrecommendations@esmo.org

The first 150 words of the full text of this article appear below.


   introduction
 
Colorectal cancer (CRC) is a multifactorial disease and the etiology is complex. It involves dietary and other environmental factors, and in between 15 and 30% of cases, inherited genetic factors are significant. Approximately 5% of all colorectal cancers occur in the setting of a well described inherited syndrome like Lynch syndrome (Hereditary Non-Polyposis Colorectal Cancer; HNPCC), (Attenuated) Familial Adenomatous Polyposis ((A)FAP), and MUTYH-associated polyposis (MAP).


   familial colorectal cancer
 
In families with clustering of CRC, but without evidence for one of the inherited syndromes, we deal with familial colorectal cancer. Subjects with one first degree relative (FDR) with CRC diagnosed at age >50 years, have a relative risk of developing CRC of 2–3. Subjects with two (or more) FDRs with CRC diagnosed at any age, or with one FDR with CRC . . . [Full Text of this Article]


   Lynch syndrome
 
incidence
diagnosis
staging and risk assessment

   treatment
 
surgical management of colorectal cancer
chemotherapy
surveillance

   (attenuated) familial adenomatous polyposis and MUTYH-associated adenomatous polyposis
 
incidence
diagnosis
FAP.
MAP.
staging and risk assessment
FAP.
MAP.
treatment
FAP.
chemoprevention
MAP.
surveillance prior to surgery in FAP
surveillance prior to surgery in MAP
surveillance after surgery in FAP and MAP

   note
 

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