Annals of Oncology 2005 16(10):1563; doi:10.1093/annonc/mdi327
© 2005 European Society for Medical Oncology
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Pemetrexed/gemcitabine versus gemcitabine in pancreatic cancer
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Pancreatic cancer accounts for more than 200 000 deaths worldwide
each year, with most patients presenting with unresectable,
locally advanced or metastatic disease. In multiple phase III
studies in patients with pancreatic cancer, single-agent gemcitabine
has shown response rates of 5.426%, median survival of
approximately 6 months and 1-year survival of approximately
20%. Pemetrexed, a multitargeted antifolate, has demonstrated
single-agent activity in pancreatic cancer with a response rate
of 5.7%, median
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Single-agent rituximab for follicular or mantle cell lymphoma
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Lung cancer mortality in European women
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Imatinib and hydroxyurea in glioblastoma multiforme
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