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Annals of Oncology 2005 16(1):4-6; doi:10.1093/annonc/mdi104
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© 2005 European Society for Medical Oncology

Editorial

Prognostic factors in ovarian cancer: how close are we to a complete picture?

R. Agarwal and S. B Kaye*

* Section of Medicine, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UKEmail: stan.kaye@rmh.nhs.uk

The first 10% of the full text of this article appears below.

Ovarian cancer is the fourth most common cause of cancer-related death in women, but is the most lethal of the gynaecological malignancies with 30–40% overall survival at 5 years [1Go]. This is in part because the majority of patients with ovarian cancer present with advanced disease, and treatment options at presentation are confined to a combination of debulking surgery and platinum based chemotherapy, which are only partially effective [2Go]. Consequently, almost all patients with advanced disease ultimately relapse and die of their disease. Advances in the management of these patients are therefore urgently required.

 Prognostic factors are defined as phenotypes which correlate with overall survival. In general prognostic factors reflect the intrinsic biology of a tumour (e.g. histological subtype, grade), disease extent (e.g. stage) and/or the capacity of a patient to cope with the morbidity associated with the tumour and treatment (e.g. . . . [Full Text of this Article]


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