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Annals of Oncology 15:363-364, 2004
© 2004 European Society for Medical Oncology

Dysphagia and aspiration following chemo-irradiation of head and neck cancer: major obstacles to intensification of therapy

Avraham Eisbruch

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA (E-mail: eisbruch@umich.edu)

The first 10% of the full text of this article appears below.

Recent improvements in the therapy of head and neck cancer have largely been the result of intensification of treatment: either the delivery of radiotherapy (RT) concurrent with chemotherapy, or altered fractionated RT, notably accelerated regimens [1, 2]. Intensification of therapy has achieved improved tumor response and local/regional control rates; however, it has often been associated with higher rates of severe early and late mucosal and pharyngeal toxicities. Acute mucosal toxicity may be addressed by measures such as transient gastric tube feeding. Persistent long-term pharyngeal toxicity—in some cases, a consequence of acute mucosal injury—is a major detrimental effect of some organ preservation approaches using chemotherapy-RT . . . [Full Text of this Article]


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D. I. Rosenthal, J. S. Lewin, and A. Eisbruch
Prevention and Treatment of Dysphagia and Aspiration After Chemoradiation for Head and Neck Cancer
J. Clin. Oncol., June 10, 2006; 24(17): 2636 - 2643.
[Abstract] [Full Text] [PDF]