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Annals of Oncology 13:501-502, 2002
© 2002 European Society for Medical Oncology

Editorial

Inhibition of bcl-2 as cancer therapy

F. Ciardiello and G. Tortora

Cattedra di Oncologia Medica, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Università degli studi di Napoli "Federico II", Naples, Italy (E-mail: fortunatociardiello@yahoo.com)

Emerging novel strategies of cancer treatment are based on the selective down-regulation of specific molecular targets involved in the process of neoplastic development and progression [1]. Antisense nucleic acids that bind to specific mRNAs have been shown, in cell cultures and in preclinical models, to be effective agents for interfering with the endogenous expression of several mammalian genes [2]. Increasing experimental evidence has been provided to support the view that antisense-induced reduction in the expression of genes directly involved in cancer development and progression could inhibit cancer cell growth [3–4]. Antisense oligonucleotides are short synthetic sequences of DNA or RNA capable of hybridising specifically to the mRNA of a chosen target gene [3]. Antisense oligonucleotides . . . [Full Text of this Article]

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