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Annals of Oncology Advance Access published online on November 5, 2009
Annals of Oncology, doi:10.1093/annonc/mdp507
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Relationship between NFKB1 –94 insertion/deletion ATTG polymorphism and susceptibility of cervical squamous cell carcinoma risk

B. Zhou1, M. Qie2, Y. Wang3, L. Yan2, Z. Zhang2, A. Liang2, T. Wang1, X. Wang1, Y. Song1 and L. Zhang1,*

1 Laboratory of Molecular Translational Medicine
2 Department of Obstetrics and Gynecology, West China Second University Hospital
3 Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, People's Republic of China

* Correspondence to: Prof. L. Zhang, Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, People's Republic of China. Tel: +86-28-85469033; Fax: +86-28-85401825; E-mail: zhanglin{at}scu.edu.cn

Background: A very high expression of nuclear factor-kappa B protein (nuclear p50, encoded by NFKB1) in high-grade squamous intraepithelial lesion and invasive cancers has been observed. The aim of this study was to determine whether the functional NFKB1 –94 insertion/deletion ATTG polymorphism (rs28362491) is associated with cervical squamous cell carcinoma (CSCC).

Materials and methods: PCR–polyacrylamide gel electrophoresis method was used to genotype the NFKB1 –94 insertion/deletion ATTG polymorphism in 233 women with CSCC and 365 ethnicity-matched healthy control women. The genotyping method was confirmed by the DNA sequencing analysis.

Results: The frequency of ATTG2/ATTG2 genotype and ATTG2 allele in the CSCC patients was significantly higher than that of controls, indicating that the –94 insertion/deletion ATTG polymorphism in NFKB1 promoter was associated with CSCC [P = 0.001, odds ratio (OR) = 2.560, 95% confidence interval (CI) 1.459–4.492 and P = 0.001, OR = 1.493, 95% CI 1.168–1.908, respectively]. Results of stratified analyses revealed that this polymorphism is associated with younger age (≤35 years) and positive parametrial invasion but not with tumor differentiation, high clinical stage or lymph node status.

Conclusion: Our results indicate that the functional NFKB1 –94 insertion/deletion ATTG polymorphism is associated with CSCC, especially with younger age (≤35 years) and positive parametrial invasion of CSCC patients.

cervical squamous cell carcinoma, NFKB1, polymorphism, risk

Received for publication August 25, 2009. Revision received September 27, 2009. Accepted for publication September 28, 2009.


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