Skip Navigation



Annals of Oncology Advance Access published online on October 27, 2009
Annals of Oncology, doi:10.1093/annonc/mdp475
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Park, J. S.
Right arrow Articles by Kim, J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Park, J. S.
Right arrow Articles by Kim, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Outcomes after repeated resection for recurrent pulmonary metastases from colorectal cancer

J. S. Park1, H. K. Kim1, Y. S. Choi1, K. Kim1, Y. M. Shim1, J. Jo2, W.-Y. Lee3, H.-K. Chun3, Y. S. Park4, W. K. Kang4 and J. Kim1,*

1 Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
2 Cancer Research Center, Center for Clinical Research, Samsung Biomedical Research Institute
3 Department of Surgery
4 Division of Hematology–Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

* Correspondence to: Prof. J. Kim, Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, 50 Ilwon-dong, Gangnam-gu, Seoul 135-710, South Korea. Tel: +82-2-3410-3483; Fax: +82-2-3410-6986; E-mail: jkimsmc{at}skku.edu

Background: It remains controversial whether metastasectomy is still feasible in patients with pulmonary recurrence from colorectal cancer, after initial metastasectomy. The aim of this study was to evaluate outcomes of repeated metastasectomy in these patients.

Materials and methods: From 1995 to 2007, 202 patients had received a pulmonary metastasectomy from colorectal cancer at our institution. Over a median follow-up of 28.9 months, 48 patients received second metastasectomy (29 wedge resections, 5 segmentectomies, 13 lobectomies, and 1 completion pneumonectomy). The median disease-free interval was 9.6 months. Among these 48 patients, 28 showed pulmonary recurrence again and of those, 10 patients received third metastasectomy (two wedge resections, two segmentectomies, four lobectomies, and two completion pneumonectomies).

Results: There was no postoperative mortality. Of the 48 patients who underwent second metastasectomy, overall and disease-free 5-year survivals were 79% and 49%, respectively, after second operation. Of the 10 patients who received third metastasectomy, overall survival was 78% at 5 years after last operation.

Conclusions: Repeated resection after initial metastasectomy can be carried out safely and provides long-term survival in patients with recurrent pulmonary metastasis from colorectal cancer. Our findings indicate that close follow-up for the early detection of recurrence and parenchyma-saving resection can improve the results after repeated resection.

colorectal cancer, pulmonary metastasis, repeated metastasectomy

Received for publication July 13, 2009. Revision received August 25, 2009. Accepted for publication August 27, 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.