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Annals of Oncology Advance Access published online on October 25, 2009
Annals of Oncology, doi:10.1093/annonc/mdp426
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Management of occult invasive cervical cancer found after simple hysterectomy

J.-Y. Park, D.-Y. Kim, J.-H. Kim, Y.-M. Kim, Y.-T. Kim and J.-H. Nam*

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

* Correspondence to: Dr J.-H. Nam, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Poongnap-2 Dong, Songpa-Gu, Seoul 138-736, Korea. Tel: +82-2-3010-3633; Fax: +82-2-476-7331; E-mail: jhnam{at}amc.seoul.kr

Background: To estimate safety and efficacy of radical parametrectomy (RP) and radiation therapy (RT) or concurrent chemoradiation therapy (CCRT) for patients with occult invasive cervical cancer found after simple hysterectomy.

Materials and methods: We retrospectively evaluated outcomes in 147 patients with occult invasive cervical cancer.

Results: Forty-eight patients with IA1 lesions (IA1 group) did not receive further treatment. Of the 99 patients with IA2–IIA lesions, 26 received no definitive treatment (observation group), 44 received RT or CCRT (RT/CCRT group), and 29 underwent RP (RP group). After a median follow-up of 116 months (range 3–235 months), recurrent disease was observed in 0%, 34.6%, 6.8%, and 0% of patients in the IA1, observation, RT/CCRT, and RP groups, respectively. In the RT/CCRT group, treatment was delayed due to severe diarrhea in 4 patients (9%) and 12 patients (27%) had late complications related to RT requiring further management (including two surgical interventions). Five patients in the RP group (17%) experienced perioperative complications which were easily managed, intraoperatively or conservatively. Late complications were not observed in the RP group.

Conclusion: Although RP and RT/CCRT had similar therapeutic efficacy, the lower rate of late complications observed with RP makes it preferable to RT/CCRT.

concurrent chemoradiation therapy, occult cervical cancer, radiation therapy, radical parametrectomy, simple hysterectomy

Received for publication May 28, 2009. Revision received July 14, 2009. Accepted for publication July 29, 2009.


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