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Annals of Oncology Advance Access published online on October 22, 2009
Annals of Oncology, doi:10.1093/annonc/mdp402
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Decreasing incidence of gastric MALT lymphomas in the era of anti-Helicobacter pylori interventions: results from a population-based study on extranodal marginal zone lymphomas

S. Luminari1,*, M. Cesaretti1, L. Marcheselli1, I. Rashid2, S. Madrigali1, A. Maiorana3 and M. Federico1

1 Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena
2 Modena Cancer Registry, Modena, Italy
3 Department of Laboratory, Pathology and Legal Medicine, University of Modena and Reggio Emilia, Modena, Italy

* Correspondence to: Dr S. Luminari, Department of Oncology and Hematology, University of Modena and Reggio Emilia, Via del pozzo 71, 41100, Modena, Italy. Tel: +39 059 4222577; Fax: +39 059 4223602; E-mail: sluminari{at}unimore.it

Background: Few studies have been carried out to date that have addressed the epidemiology of extranodal marginal zone lymphomas (EN-MZLs).

Patients and methods: We carried out a population-based study to investigate incidence rates (IRs) and time trends of EN-MZL diagnosed in the province of Modena (Italy) from 1997 to 2007.

Results: One hundred and sixty-five cases were identified from the Modena Cancer Registry that corresponded to an age-standardized IR of 2.3 cases per 100 000. A bimodal distribution of age was shown with the group of young patients mostly represented by males with cutaneous lymphoma. No time trends were observed for the IR; the incidence of gastric mucosa-associated lymphoid tissue (g-MALT) lymphomas (N = 51) markedly declined during the study period, dropping from 1.4 in 1997 to 0.2 in 2002 and then remaining stable until 2007; the calculated annual percent change for g-MALT was –17.0% (95% confidence interval –26.6% to –6.2%). We also observed a significant decrease in the rate of g-MALT associated with Helicobacter pylori (HP) infection from 61% to 17% of patients diagnosed before and after 2002 (P = 0.007; P for trend = 0.016).

Conclusion: This population-based study provides new insights into recent changes in the epidemiology of EN-MZL, mainly represented by the sharp reduced incidence of HP-positive g-MALT lymphomas.

extranodal lymphoma, gastric MALT, Helicobacter pylori, incidence change, non-Hodgkin’s lymphoma, population-based study

Received for publication May 22, 2009. Revision received July 9, 2009. Accepted for publication July 10, 2009.


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