Annals of Oncology Advance Access published online on October 13, 2009
Annals of Oncology, doi:10.1093/annonc/mdp380
review |
Dismissing links between HPV and aggressive tongue cancer in young patients
Department of Surgery, Al-Bayader Hospital, Amman, Jordan
* Correspondence to: Dr A. Salem, Department of Surgery, Al-Bayader Hospital, 8th Circle, Amman 11814, Jordan. Tel: +962-788-305344; Fax: +962-6-5857323; E-mail: alwikah{at}hotmail.com
Background: The objective of this study is to disprove and dismiss etiological links between human papillomavirus (HPV) and aggressive tongue cancer in young patients.
Methods: Review of available literature with focus on presenting the epidemiological, histological and immunohistochemical arguments against an association between HPV and aggressive glossal neoplasm in younger populations.
Conclusion: HPV is not associated with the recent surge in the incidence of biologically aggressive oral cavity cancer in young populations.
cancer, HPV, oral, oropharynx, tongue, young
Received for publication March 23, 2009. Revision received May 5, 2009. Accepted for publication June 26, 2009.