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Annals of Oncology Advance Access published online on October 13, 2009

Annals of Oncology, doi:10.1093/annonc/mdp380
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

review

Dismissing links between HPV and aggressive tongue cancer in young patients

A. Salem*

Department of Surgery, Al-Bayader Hospital, Amman, Jordan

* Correspondence to: Dr A. Salem, Department of Surgery, Al-Bayader Hospital, 8th Circle, Amman 11814, Jordan. Tel: +962-788-305344; Fax: +962-6-5857323; E-mail: alwikah{at}hotmail.com

Background: The objective of this study is to disprove and dismiss etiological links between human papillomavirus (HPV) and aggressive tongue cancer in young patients.

Methods: Review of available literature with focus on presenting the epidemiological, histological and immunohistochemical arguments against an association between HPV and aggressive glossal neoplasm in younger populations.

Conclusion: HPV is not associated with the recent surge in the incidence of biologically aggressive oral cavity cancer in young populations.

cancer, HPV, oral, oropharynx, tongue, young

Received for publication March 23, 2009. Revision received May 5, 2009. Accepted for publication June 26, 2009.


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