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Annals of Oncology Advance Access published online on August 27, 2009
Annals of Oncology, doi:10.1093/annonc/mdp369
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

review

Drug interactions in oncology: how common are they?

R. P. Riechelmann1,* and A. Del Giglio2

1 Internal Medicine, Federal University of Sao Paulo
2 Medical Oncology, ABC School of Medicine, Sao Paulo, Brazil

* Correspondence to: Dr R. P. Riechelmann, Internal Medicine, Federal University of Sao Paulo, Avenue Vicente Rao 90, Sao Paulo, SP 04560070, Brazil. Tel: +55-11-99320868; Fax: +55-11-55327702; E-mail: rachelri{at}terra.com.br

Background: Drug–drug interactions (DDIs) comprise an important problem in medical oncology practice. We systematically reviewed the frequency of DDIs in oncology.

Methods: We searched PubMed for eligible articles and on-line databases for abstracts of major oncology meetings.

Results: Eight studies reported on the frequency of DDIs: six evaluated the frequency of potential DDIs, while two studies reported on real DDIs, i.e. interactions that had clinical consequences. Studies of potential DDIs found that approximately one-third of patients are exposed to dangerous drug doublets, with the most common ones involving warfarin and anticonvulsants. One study of real DDIs found that 2% of hospitalized cancer patients had a DDI as the cause of admission.

Conclusions: Drug interactions comprise an important issue in oncology, with approximately one-third of ambulatory cancer patients being at risk of DDIs. Data are limited on the clinical consequences of drug interactions among cancer patients.

adverse effects, drug interactions, drug therapy, neoplasms

Received for publication June 14, 2009. Accepted for publication June 22, 2009.


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