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Annals of Oncology Advance Access published online on September 16, 2009
Annals of Oncology, doi:10.1093/annonc/mdp338
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

IVS10+12A>G polymorphism in hMSH2 gene associated with prognosis for patients with colorectal cancer

J. G. Kim1, Y. S. Chae1, S. K. Sohn1, J. H. Moon1, B. W. Kang1, J. Y. Park2, S. W. Jeon3, M.-H. Lee4,5, K.-H. Lim6, G. S. Choi6,* and S.-H. Jun6

1 Department of Oncology/Hematology, Kyungpook National University Hospital, Kyungpook National University School of Medicine
2 Department of Internal Medicine and Biochemistry, Kyungpook National University Hospital, Kyungpook National University School of Medicine
3 Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine
4 Technology Center for Diagnosis and Prediction, Kyungpook National University Hospital, Kyungpook National University School of Medicine
5 D&P Biotech, Ltd
6 Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea

* Correspondence to: Dr G. S. Choi, Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 50 Samduck 2-Ga, Jung-Gu, Daegu 700-712, Korea. Tel: +82-53-420-6522; Fax: +82-53-426-2046; E-mail: kyuschoi{at}mail.knu.ac.kr

Background: The polymorphisms in DNA repair genes may contribute to a variation in the DNA repair capacity, thereby affecting the risk of carcinogenesis and prognosis of colorectal cancer. Accordingly, the present study analyzed 14 polymorphisms in DNA repair genes and their impact on the prognosis for patients with colorectal cancer.

Materials and methods: Three hundred and ninety-seven consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in the present study. The genomic DNA was extracted from fresh colorectal tissue and 14 polymorphisms of DNA repair genes determined using a real-time PCR genotyping assay.

Results: The median age of the patients was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%) patients had rectal cancer. A multivariate survival analysis, including age, differentiation, carcinoembryonic antigen level, and stage, revealed a better survival for the patients with the combined IVS10+12AG and GG genotype than for the patients with the IVS10+12AA genotype [disease-free survival: hazard ratio (HR) 0.47, 95% confidence interval (CI) 0.30–0.75, P = 0.002; overall survival: HR 0.50, 95% CI 0.26–0.98, P = 0.042]. None of the other polymorphisms was associated with survival.

Conclusion: The IVS10+12A>G polymorphism in the hMSH2 gene was found to be an independent prognostic marker for patients with colorectal cancer.

colorectal cancer, hMSH2, polymorphism, prognosis

Received for publication April 22, 2009. Revision received May 20, 2009. Accepted for publication May 25, 2009.


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