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Annals of Oncology Advance Access published online on September 16, 2009
Annals of Oncology, doi:10.1093/annonc/mdp333
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© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Fascin1 expression predicts poor prognosis in patients with nasopharyngeal carcinoma and correlates with tumor invasion

D. Wu1, L. Chen1, W. Liao2, Y. Ding3, Q. Zhang3, Z. Li3 and L. Liu4,*


1 Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
2 Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
3 Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
4 Department of Health Administration, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China

* Correspondence to: Dr L. Liu, Department of Health Administration, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. Tel: +86-20-62787693; Fax: +86-20-61642131; E-mail: liliu.gd{at}gmail.com

Background: The purpose of this study was to investigate prognostic significance of fascin1 in nasopharyngeal carcinoma (NPC) and evaluate the association of fascin1 with tumor invasion.

Materials and methods: Immunohistochemical staining for fascin1 was carried out on paraffin-embedded tissue sections from 161 patients with NPC. Data were subjected to statistical analysis with respect to clinicopathological variables and survival. Small interfering RNA (siRNA) approach was used to knockdown fascin1 expression in NPC cells to determine whether fascin1 contributes to tumor cell invasion.

Results: Immunohistochemical analysis showed that fascin1 was highly expressed in 95 (59.0%) of 161 paraffin-embedded NPC tissues. Fascin1 expression was significantly correlated with clinical stage (P < 0.001) and N classification (P < 0.001). Statistical analysis showed that fascin1 expression was inversely correlated with both overall and disease-free survival of NPC patients. Multivariate analysis showed that fascin1 expression was an independent prognostic indicator for patient's survival. Moreover, disruption of endogenous fascin1 expression in NPC cells using siRNA technique suppressed NPC cell invasiveness and decreased cell filopodia and lamellopodia.

Conclusion: The present study indicates that fascin1 expression is inversely correlated with NPC patient survival and directly correlated with the malignant status of NPC.

fascin1, nasopharyngeal carcinoma, prognosis

Received for publication July 14, 2008. Revision received April 26, 2009. Accepted for publication May 27, 2009.


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