Skip Navigation



Annals of Oncology Advance Access published online on July 21, 2009
Annals of Oncology, doi:10.1093/annonc/mdp298
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Anaya, D. A.
Right arrow Articles by Pollock, R. E.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anaya, D. A.
Right arrow Articles by Pollock, R. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Postoperative nomogram for survival of patients with retroperitoneal sarcoma treated with curative intent

D. A. Anaya1, G. Lahat2, X. Wang3, L. Xiao3, P. W. Pisters2, J. N. Cormier2, K. K. Hunt2, B. W. Feig2, D. C. Lev4 and R. E. Pollock2,*

1 Department of Surgery, Baylor College of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX
2 Department of Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
3 Department of Biostatistics, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
4 Department of Cancer Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

* Correspondence to: Dr R. E. Pollock, Department of Surgical Oncology, Unit 444, University of Texas M.D. Anderson Cancer Center, 1400 Holcombe Boulevard, PO Box 301402, Houston, TX 77030-4009, USA. Tel: +1-713-792-6928; Fax: +1-713-792-4689; E-mail: rpollock{at}mdanderson.org

Background: Current American Joint Committee on Cancer retroperitoneal sarcoma (RPS) staging is not representative of patients with RPS specifically and has limited discriminative power. Our objective was to develop a RPS disease-specific nomogram capable of stratifying patients based on probability of overall survival (OS) after resection.

Patients and methods: In all, 1118 RPS patients were evaluated at our institution (1996–2006). Patients with resectable, nonmetastatic disease were selected (n = 343) and baseline, treatment and outcome variables were retrieved. A nomogram was created and its performance was evaluated by calculating its discrimination (concordance index) and calibration and by subsequent internal validation.

Results: Median follow-up and OS were 50 and 59 months, respectively. Independent predictors of OS were included in the nomogram: age (≥65), tumor size (≥15 cm), type of presentation (primary versus recurrent), multifocality, completeness of resection and histology. The concordance index was 0.73 [95% confidence interval (CI) 0.71–0.75] and the calibration was excellent, with all observed outcomes within the 95% CI of each predicted survival probability.

Conclusions: A RPS-specific postoperative nomogram was developed. It improves RPS staging by allowing a more dynamic and robust disease-specific risk stratification. This prognostic tool can help in patient counseling and for selection of high-risk patients that may benefit from adjuvant therapies or inclusion into clinical trials.

postoperative nomogram, prognosis, retroperitoneal sarcoma, staging

Received for publication January 19, 2009. Revision received April 24, 2009. Accepted for publication April 27, 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.