Skip Navigation


Annals of Oncology Advance Access originally published online on June 30, 2009
Annals of Oncology 2009 20(12):1936-1942; doi:10.1093/annonc/mdp235
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
20/12/1936    most recent
mdp235v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by De Cicco, M.
Right arrow Articles by Veronesi, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Cicco, M.
Right arrow Articles by Veronesi, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

supportive and palliative care

Early and short-term acenocumarine or dalteparin for the prevention of central vein catheter-related thrombosis in cancer patients: a randomized controlled study based on serial venographies

M. De Cicco1,*, M. Matovic1, L. Balestreri2, A. Steffan3, R. Pacenzia1, M. Malafronte1, D. Fantin1, C. A. Bertuzzi1, F. Fabiani1, S. Morassut2, E. Bidoli4 and A. Veronesi5

1 Department of Anaesthesiology and Intensive Care
2 Department of Radiology
3 Department of Laboratory Diagnostics, National Cancer Institute, Aviano (PN), Italy
4 Department of Biostatistics and Epidemiology Unit
5 Department of Medical Oncology, National Cancer Institute, Aviano (PN), Italy

* Correspondence to: Dr M. De Cicco, Department of Anaesthesiology and Intensive Care, National Cancer Institute, Via Franco Gallini, 2, 33170 Aviano (PN), Italy. Tel: +39-0434659437; Fax: +39-0434659858; E-mail: mdecicco{at}cro.it

Background: We evaluated efficacy and safety of early and short-term prophylaxis with acenocumarine or dalteparin in the prevention of non-occlusive or occlusive central vein catheter-related thrombosis (CVCrT).

Patients and methods: Consecutive cancer patients scheduled for chemotherapy randomly received: acenocumarine 1 mg/day for 3 days before and 8 days after central vein catheter (CVC) insertion; dalteparin 5000 IU 2 h before and daily for 8 days after CVC insertion; no anticoagulant treatment (NT). All patients underwent venography on days 8 and 30, some of them on days 90, 150 and 210 after CVC.

Results: A total of 450 patients were randomized, 348 underwent at least two venography. Both acenocumarine and dalteparin reduced venography-detected CVCrT rate [21.9% acenocumarine versus 52.6% NT, odds ratio (OR) 0.3, P < 0.01; 40% dalteparin versus 52.6% NT, OR 0.6, P = 0.05]. Acenocumarine was more effective than dalteparin (OR 0.4, P = 0.01). The rate of occlusive CVCrT was not different in the three groups (0.9% acenocumarine, 3.3% dalteparin, 1.8% NT; P = 0.40). Most CVCrTs (95.6%) were observed on day 8 after CVC insertion and were non-occlusive.

Conclusions: In this study of early and short-term prophylaxis, acenocumarine was more effective than dalteparin on non-occlusive and asymptomatic CVCrT events. The first days following CVC insertion represent the highest risk for CVCrT.

Key words: cancer patients, central vein catheter-related thrombosis, thromboprophylaxis

Received for publication February 6, 2009. Accepted for publication March 16, 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.