Annals of Oncology Advance Access published online on November 27, 2006
Annals of Oncology, doi:10.1093/annonc/mdl428
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1 Program in Peritoneal Surface Oncology, Washington Cancer Institute, Washington Hospital Center, Washington, DC
* To whom correspondence should be addressed. Background: In the past, diffuse malignant peritoneal mesothelioma (DMPM) was regarded as a preterminal condition. The length of survival was dependent upon the aggressive versus indolent biologic behavior of the neoplasm. The overall median survival was Patients and methods: Searches for relevant studies published in peer-reviewed medical journals on CRS and PIC for DMPM before May 2006 were carried out on six databases. The reference lists of all retrieved articles were reviewed for further identification of potentially relevant studies. Expert academic surgeons in Washington, DC, USA were asked whether they knew about any important unpublished data. Two investigators independently evaluated each study according to predefined criteria. The quality of each study was assessed. Clinical effectiveness was synthesized through a narrative review with full tabulation of results of all included studies. Results: Seven prospective observational studies from six tertiary institutions were available, allowing 240 DMPM patients for assessment. The median survival ranged from 34-92 months. The 1-, 3- and 5-year survival varied from 60% to 88%, 43% to 65% and 29% to 59%, respectively. The perioperative morbidity varied from 25% to 40% and mortality ranged from 0% to 8%. Conclusions: This systematic review evaluated the current evidence for CRS and PIC for DMPM. Seven observational studies were available for assessment, which demonstrated an improved overall survival, as compared to historical controls, using systemic chemotherapy and palliative surgery.
Received July 21, 2006
Revised October 13, 2006
Accepted October 17, 2006
review
A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma
T. D. Yan 1, L. Welch 2, D. Black 3, and P. H. Sugarbaker 1 *
2 Center to Protect Worker's Rights, Silver Spring, MD, USA
3 School of Public Health and Community Medicine, The University of New South Wales, Sydney, Australia
P. H. Sugarbaker, E-mail: paul.sugarbaker{at}medstar.net
Abstract 
1 year after systemic chemotherapy. Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) has been used as a treatment alternative, but the efficacy of this combined treatment remains to be established.
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