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Annals of Oncology Advance Access published online on January 24, 2005
Annals of Oncology, doi:10.1093/annonc/mdi093
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© 2005 European Society for Medical Oncology
Received August 9, 2004
Revised October 26, 2004
Accepted October 29, 2004

Original article

FDG-PET scanning for detection and staging of extranodal marginal zone lymphomas of the MALT type: a report of 42 cases

K. P. Beal 1, H. W. Yeung 2, and J. Yahalom 1*

1 Departments of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
2 Department ofNuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

* To whom correspondence should be addressed.
J. Yahalom, E-mail: yahalomj{at}mskcc.org


  Abstract

Background: Although reports have suggested that FDG-PET scans were not useful for staging of extranodal marginal zone lymphomas (MZL), experience at our center suggests otherwise. Thus we reviewed the findings of FDG-PET scans in patients with extranodal MZL seen at our center.

Patients and methods: A database of 175 patients with histologically-confirmed diagnoses of extranodal MZL was reviewed. Forty-two patients who had had FDG-PET scans for initial staging were identified. All information was obtained by retrospective review of medical records and PET scans.

Results: Thirty-four (81%) patients had focal tracer uptake within verified tumor sites, six (14%) patients did not, and two (5%) patients had indeterminate uptake. Seven of the 34 (21%) patients with uptake within verified tumor sites had uptake in regional lymph nodes and four patients were upstaged due to FDG-PET findings. Eight patients also obtained post-treatment FDG-PET scans. In five of those eight, the repeated FDG-PET scan indicated a complete response, and in three there was an indeterminate or mixed response.

Conclusion: FDG-PET scans carried out for initial staging of extranodal MZL detected disease in a high proportion of patients. This study suggests that imaging with FDG-PET scans is useful for both initial staging and follow-up of patients with extranodal MZL.

Keywords: MALT lymphoma; PET scan.
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