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Annals of Oncology 9:S31-S38, 1998
© 1998 European Society for Medical Oncology

Reviews

Workshop report on Hodgkin's disease and related diseases (‘grey zone’ lymphoma)

T. Rüdiger1, E. S. Jaffe2, G. Delsol3, C. deWolf-Peeters4, R. D. Gascoyne5, A. Georgii6, N. L. Harris7, M. E. Kadin8, K. A. MacLennan9, S. Poppema10, H. Stein11, L. E. Weiss12 and H. K. Müller-Hermelink1

1 University of Würzburg Germany
2 Laboratory of Pathology, National Cancer Institute Bethesda, USA
3 CHU Purpan Toulouse France
4 University of Leuven Belgium
5 British Columbia Cancer Agency Vancouver, Canada
6 Medizimsche Hochschule Hannover Germany
7 Massachusetts General Hospital
8 Beth Israel Hospital Boston, USA
9 St James University Hospital Leeds, UK
10 University of Groningen The Netherlands
11 Universitdtsklinikum Benjamin Franklin Berlin, Germany
12 City of Hope National Medical Center Duarte. USA

Correspondence to: Th. Rüdiger, Institute of Pathology, Josef-Schneider-Str. 2, D-97080 Würzburg, Germany, E-mail thomas.ruediger{at}mail.ini-wuerzburg.de

Despite advances in immunohistochemistry and molecular biology, the distinction between classical Hodgkin's lymphoma and related diseases such as nodular lymphocyte-predominant Hodgkin's disease, T-cell rich large B-cell lymphoma or ana-plastic large cell lymphoma has remained difficult in rare cases. Lack of clear-cut diagnostic criteria represents a problem for both the pathologist and the clinician.

To delineate this ‘grey zone’ between classical Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL) and to develop criteria for classification of such cases, 12 expert hematopathologists each submitted one to five borderline cases to a workshop. Cases were reviewed and classified at a multi-headed microscope and criteria were established for the diagnosis of questionable cases. Well established entities such as classical Hodgkin's lymphoma, anaplastic large-cell lymphoma and TCRBCL were defined more strictly and cases with unusual morphology or antigen expression could be identified. A distinctive subset of cases representing mediastinal large B-cell lym-phomas with features of Hodgkin's lymphoma was identified.

differential diagnosis, grey zone, Hodgkin's lymphoma, immunohistochemistry, pathology, workshop report


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