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Annals of Oncology 9:S125-S128, 1998
© 1998 European Society for Medical Oncology

Reviews

Molecular basis of targeted chemotherapy: Novel concepts with special reference to the treatment of Hodgkin's disease

H. H. Grunicke, Dr.

Institute of Medical Chemistry and Biochemistry, University of Innsbruck Innsbruck, Austria

Correspondence to: Dr. H.H. Grunicke Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz-Pregl-StraBe, A-6020Innsbruck, Austria

Concepts for the treatment of Hodgkin's lymphomas based on novel insights of the molecular mechanisms responsible for the maintenance of the transformed phenotype of Reed-Sternberg cells, their proliferation and sensitivity to radiation and anti-tumor agents are discussed. The potentials of some recently developed new signal transduction inhibitors for the treatment of Hodgkin's lymphomas are discussed in greater detail and comprise agents directed against Janus kinase 2 (JAK 2); Signal Transducers and Activators of Transcription (STAT factors); agents directed against SH 2-domains; the fes/fps oncogene, Ras; protein kinase C (PKC) isotypes and means of inducing radiation or drug-induced apoptosis.

bcl-2, fes/fps, JAK, protein kinase C, Raf-1, Ras, STAT


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