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Annals of Oncology 8:S49-S54, 1997
© 1997 European Society for Medical Oncology

Changing trends in the incidence of non-Hodgkin's lymphoma in Europe

G. Morgan1, M. Vornanen2, J. Puitinen2, A. Naukkarinen2, H. Brincker3, J. Olsen4, J. W. Coeburgh5, L. W. M. A. Vrints5, D. Clayden6, R. McNally6, A. Jack6, R. Cartwright6, P. M. Carli7, T. Petrella7, R. Tomino8, S. D'Lollo8, A. Barchielli9 and on behalf of the Biomed Study Group

1 Department of Molecular Haematology, University of Leeds Leeds, UK
2 Finish Cancer Registry Finland
3 LYFO Cancer Registry Odense
4 Danish National Cancer Registry Odense, Denmark
5 Comprehensive Cancer Care Center South Eindhoven, the Netherlands
6 Leukaemia Research Fund Clinical Centre Epidemiology, Leeds, UK
7 Cancer Registry of the Côte d'Or Dijon, France
8 Ragussa Cancer Registry Ragussa
9 Florence Cancer Registry Florence, Italy

Correspondence to: G. Morgan Department of Molecular Haematology Algernon Firth Building University of Leeds Leeds LS2 9JT, UK

Non-Hodgkin's lymphoma (NHL) is not a uniform disease entity, and in order to investigate the reported changes in incidence we have set up a study in seven population-based cancer registries in Europe. The study is designed to look at changes in the incidence of total NHL and disease subgroups using standard definitions and methodology. The registries are based in Leeds, Dijon, Kuopio, Odense, Florence, Eindhoven, and Ragussa. The classification system we have used is based on the REAL classification and has utility for epidemiological studies. We have used it to convert data sets which have utilized both local cases and the ICD-O classification. In order to improve data reproducibility, CLL/LL, myeloma/MGUS, lymphoblastic disease, and Hodgkin's disease have been excluded because of the difficulty in defining incident cases accurately. The preliminary results of this study show that there is still an upward trend in incidence rate and that in Yorkshire this is 3% per annum in total NHL. The subgroups which are increasing are extranodal and nodal peripheral T-cell lymphoma. Similar increases in incidence have been reported for the other registries. We conclude that there is a continued upward trend in incidence of NHL, the causes of which are uncertain.

changing incidence, epidemiology, NHL, population-based registries, REAL


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