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Annals of Oncology 8:S41-S44, 1997
© 1997 European Society for Medical Oncology

Pathogenesis of gastric lymphoma: The enigma in Hong Kong

W. S. Xu, F. C. S. Ho, A. C. L. Chan and G. Srivastava

Department of Pathology, University of Hong Kong Hong Kong

Correspondence to: Prof. Faith C.S. Ho Department of Pathology University of Hong Kong Queen Mary Hospital Compound Pokfulam Road Hong Kong

Background Helicobacter pylori (H. pylori) infection has been postulated to be a pathogenetic factor in gastric lymphoma. However, the etiological factors for gastric lymphoma could vary in different populations.

Materials and methods: We looked for histological evidence of H. pylori infection in 53 gastrectomy specimens from Hong Kong Chinese patients with primary gastric B-lymphoma. We also screened for Epstein-Barr virus (EBV) in these cases using in situ hybridization with oligonucleotide probes for EBV-en-coded small RNA1 and 2.

Results H. pylori was found in 29 of 53 (55%), including 8 of 13 (62%) cases of low-grade lymphoma of mucosa-associated lymphoid tissue (MALT) type. These infection rates in gastric lymphoma are lower than those reported in Western populations (80%–100%) and comparable to that found in healthy Chinese blood donors (55%) or in non-ulcer dyspeptic patients (52%–57%). EBV was found in tumor cells only in one case of high-grade gastric lymphoma with low-grade MALT component which was H. pylori-negative, and in occasional nontumor lymphoid cells in 7 other cases.

Conclusions These results suggest that (1) the role of H. pylori in pathogenesis of gastric lymphoma may vary in different populations; (2) very few gastric lymphomas are associated with EBV; (3) not all low-grade gastric MALT lymphomas are H. pylori-dependent.

Epstein-Barr virus, gastric lymphoma, Helicobactor pylori, mucosa-associated lymphoid tissue


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