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Annals of Oncology 8:S105-S108, 1997
© 1997 European Society for Medical Oncology

Involvement of the bcl-6 gene in AIDS-related lymphomas

G. Gaidano1,2, C. Pastore2, D. Capello2, A. Migliazza3, A. Gloghini4, G. Saglio2,5, A. Carbone4 and R. Dalla-Favera3

1 Dipartimento di Scienze Mediche, Università di Torino Novara, Italy
2 Laboratorio di Medicina e Oncologia Molecolare, Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino Torino, Italy
3 Division of Oncology, Department of Pathology, College of Physicians and Surgeons, Columbia University New York, NY, USA
4 Divisione di Anatomia Patologica, INRCCS-Centro di Riferimento Oncologico Aviano, Italy
5 CNR-CIOS Torino, Italy

Correspondence to: Gianluca Gaidano, MD, PhD Department of Medical Sciences II Medical School University of Torino Via Solaroli 17 28100 Novara Italy

Background Non-Hodgkin's lymphoma (NHL) represents a major complication of AIDS. Systemic AIDS-related NHLs (AIDS-NHLs) derive from B cells and are classified into four distinct groups, including small noncleaved-cell lymphoma (SNCCL), diffuse large-cell lymphoma (DLCL), anaplastic large-cell lymphoma (ALCL), and body-cavity-based lymphoma (BCBL). The molecular pathogenesis of AIDS-NHL is characterized by the association of specific genetic lesions with distinct AIDS-NHL categories. Genetic lesions of AIDS-NHL involve proto-oncogenes (c-myc, Ras), tumor suppressor loci (p53, 6q), and viral infection (Epstein-Barr virus, human her-pesvirus type 8).

Design The aim of this work was to define the involvement of the bcl-6 gene in AIDS-related lymphomagenesis by investigating the distribution of bcl-6 structural alterations throughout the pathologic spectrum of AIDS-NHL. Both gross rearrangements and mutations in the 5' noncoding regions of the gene were investigated.

Results Gross rearrangements of bcl-6 are confined to a fraction of AIDS-DLCL cases among AIDS-NHLs. Conversely, mutations of the 5' noncoding regions of bcl-6 are detected in a large proportion of AIDS-SNCCLs, AIDS-DLCLs and AIDS-ALCLs independent of the concomitant presence of bcl-6 rearrangements.

Conclusions Mutations of the 5' noncoding regions of bcl-6 represent the most frequent genetic lesion presently detectable among systemic AIDS-NHLs. The frequency of these mutations and their location in the proximity of bcl-6 regulatory regions suggest that they may play a role in AIDS-related lymphomagenesis.

AIDS, bcl-6, genetic lesion, lymphoma, oncogene


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