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Annals of Oncology 8:S49-S52, 1997
© 1997 European Society for Medical Oncology

Is the International Prognostic Index for aggressive lymphomas useful for low-grade lymphoma patients? Applicability to stage 111-IV patients

C. Foussard1,1, B. Desablens2, L. Sensebe3, S. François1, N. Milpied4, E. Deconinck5, V. Delwail6, J. Dugay7, T. Lamy8, C. Ghandour9, A. Le Mevel10, H. Maisonneuve11, P. Casassus12 GOELAMS Group, France, P. Colombat13 GOELAMS Group, France

1 Departments of Hematology of Angers France
2 Departments of Hematology of Amiens France
3 Departments of Hematology of Brest France
4 Departments of Hematology of Nantes France
5 Departments of Hematology of Besançon France
6 Departments of Hematology of Poitiers France
7 Departments of Oncology of Le Mans France
8 Departments of Hematology of Rennes France
9 Departments of Oncology of Rennes France
10 Departments of Oncology of Nantes France
11 Departments of Oncology of La Roche France
12 Departments of Hematology of Bobigny France
13 Departments of Hematology of Tours France

1Correspondence to: Dr C. Foussard Department of Hematology CHU Angers 49033 Angers Cedex 01 France

Background The International Prognostic Index (IPI) is widely used to predict outcome of patients with aggressive lymphomas. Our goal was to assess the prognostic value of this index for low-grade lymphoma.

Patients and methods One hundred eighty-two patients with disseminated (stage III or IV) low-grade lymphoma were enrolled in a prospective multicenter trial. According to the initial features, treatment either was started immediately or was deferred until indicated by disease progression. Patients received the same polychemotherapy regimen, given monthly for six cycles. They were assigned to one of four risk groups according to the number of presenting risk factors: low-risk (0 or 1), low-intermediate-risk (2), high-intermediate-risk (3), high-risk groups (4).

Results Survival curves (Kaplan-Meier method) demonstrated a high significant difference for the four groups (logrank: P < 0.0001). Median survival for the low-risk group has yet to be reached, while that for the three other groups are, respectively, 65, 34, and 12 months.

Conclusions In this study, the LPI has been found to be an important prognostic tool in low-grade lymphoma and may be used in the selection of appropriate therapeutic approaches for individual patients.

index, lymphoma, low grade, prognostic factors


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